pentobarbital will reduce the level or effect of donepezil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.
pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can lessen panobinostat stages by ~70% and cause treatment method failure.
pentobarbital will decrease the level or outcome of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Contraindicated (one)pentobarbital will lessen the extent or effect of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Girls shouldn't opt for estradiol valerate/dienogest as their contraceptive whilst working with robust CYP3A4 inducers resulting from possible lower in contraceptive efficacy.
pentobarbital will reduce the extent or effect of repaglinide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
CYP3A4 inducers may perhaps enhance the formation from the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Intently watch sufferers getting ifosfamide with CYP3A4 inducers for toxicities and think about dose adjustment.
Pentobarbital features in the CNS by binding to gamma-aminobutyric acid (GABA) A subtype receptors. This motion potentiates GABA outcomes, leading to CNS depression and inhibiting glutamate, additional leading to an additive impact on CNS depression. Even though the not enough an antidote has resulted in reduced very first-line usage of your drug, its indications remain acknowledged.
pentobarbital will lower the level more info or effect of dapsone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
pentobarbital will decrease the extent or effect of propafenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
pentobarbital decreases amounts of amphotericin B deoxycholate by inhibition of GI absorption. Applies only to oral method of both agents. Minimal/Importance Unknown.
pentobarbital will lower the extent or impact of zolpidem by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.
pentobarbital will reduce the level or outcome of tacrolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lower the level or effect of estradiol vaginal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will decrease the extent or influence of estradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.